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高磊

研究員,長(cháng)聘副教授
導師類别:博士生導師
性别: 男
學(xué)曆:博士研究生
學(xué)位:博士

研究生培養

培養碩士生6人,博士研究生6人。1人被評為(wèi)北京協和醫(yī)學(xué)院優秀畢業生,1人被評為(wèi)北京市優秀畢業生。

個人簡介

中(zhōng)國(guó)醫(yī)學(xué)科(kē)學(xué)院/北京協和醫(yī)學(xué)院病原生物(wù)學(xué)研究所副所長(cháng),課題組長(cháng)。主要從事傳染病流行病學(xué)研究,重點探索适宜中(zhōng)國(guó)結核病高負擔國(guó)情的結核潛伏感染人群預防幹預新(xīn)技(jì )術和新(xīn)方案。入選教育部新(xīn)世紀優秀人才、北京市科(kē)技(jì )新(xīn)星、協和新(xīn)星等。國(guó)家傳染病标準專業委員會委員、中(zhōng)國(guó)防痨協會結核潛伏感染防治專業分(fēn)會副主任委員、中(zhōng)國(guó)防痨協會标準化專業分(fēn)會秘書長(cháng)、第一批國(guó)家健康科(kē)普專家庫成員。中(zhōng)華結核和呼吸雜志(zhì)、中(zhōng)國(guó)防痨雜志(zhì)、BMC Infectious Diseases、PLOS Global Public Health、Chronic Diseases and Translational Medicine等學(xué)術期刊編委。作(zuò)為(wèi)第一作(zuò)者或通訊作(zuò)者在Lancet Infect Diseases,European Respiratory Journal等國(guó)際學(xué)術期刊發表SCI論文(wén)50餘篇。獲中(zhōng)華預防醫(yī)學(xué)會科(kē)學(xué)技(jì )術一等獎、中(zhōng)國(guó)防痨協會科(kē)學(xué)技(jì )術一等獎、中(zhōng)華醫(yī)學(xué)科(kē)學(xué)技(jì )術二等獎、高等學(xué)校科(kē)學(xué)研究優秀成果獎自然科(kē)學(xué)類二等獎、中(zhōng)國(guó)醫(yī)學(xué)科(kē)學(xué)院“傑出貢獻獎”、中(zhōng)國(guó)醫(yī)學(xué)科(kē)學(xué)院-法國(guó)梅裏埃研究院“青年科(kē)學(xué)家獎”等。

研究方向

結核病等重大傳染病的流行病學(xué)和精(jīng)準幹預研究

科(kē)研項目

1、傳染病防治科(kē)技(jì )重大項目,2017ZX10201302-009,結核潛伏感染幹預治療效果研究 ,子課題負責人

2、傳染病防治科(kē)技(jì )重大項目,2017ZX10201302-00,肺結核人工(gōng)智能(néng)影像診斷系統的優化升級,子課題負責人

3、中(zhōng)國(guó)醫(yī)學(xué)科(kē)學(xué)院醫(yī)學(xué)與健康科(kē)技(jì )創新(xīn)工(gōng)程,2019-I2M-2-005,農村中(zhōng)老年人群結核潛伏感染流行病學(xué)調查和幹預研究隊列,課題負責人

4、傳染病防治科(kē)技(jì )重大項目,2017ZX10201302002,既往肺結核患者潛伏感染幹預手段研究,子課題負責人

 

研究成果

1、Gao L, Lu W, Bai L, Wang X, Xu J, Catanzaro A, Cárdenas V, Li X, Yang Y, Du J, Sui H, Xia Y, Li M, Feng B, Li Z, Xin H, Zhao R, Liu J, Pan S, Shen F, He J, Yang S, Si H, Wang Y, Xu Z, Tan Y, Chen T, Xu W, Peng H, Wang Z, Zhu T, Zhou F, Liu H, Zhao Y, Cheng S, Jin Q; LATENTTB-NSTM study team. Latent tuberculosis infection in rural China: baseline results of a population-based, multicentre, prospective cohort study. Lancet Infect Dis. 2015 Mar;15(3):310-9.

2、Gao L, Li X, Liu J, Wang X, Lu W, Bai L, Xin H, Zhang H, Li H, Zhang Z, Ma Y, Li M, Feng B, Du J, Sui H, Zhao R, Su H, Pan S, Guan L, Shen F, He J, Yang S, Si H, Cheng X, Xu Z, Tan Y, Chen T, Xu W, Peng H, Wang Z, Zhu T, Chen X, Zhou X, Guan X, Jin Q; LATENTTB-NSTM study team. Incidence of active tuberculosis in individuals with latent tuberculosis infection in rural China: follow-up results of a population-based, multicentre, prospective cohort study. Lancet Infect Dis. 2017 Oct;17(10):1053-1061.

3、Zhang H, Xin H, Li X, Li H, Li M, Feng B, Gao L*. Reversion of QuantiFERON-TB Gold In-Tube test in individuals with and without prophylactic treatment for latent tuberculosis infection: A systematic review and meta-analysis. J Infect. 2018 Oct;77(4):276-282.

4、Zhang H, Xin H, Wang D, Pan S, Liu Z, Cao X, Wang J, Li X, Feng B, Li M, Yang Q, Zhang M, Jin Q, Gao L*. Serial testing of mycobacterium tuberculosis infection in Chinese village doctors by QuantiFERON-TB Gold Plus, QuantiFERON-TB Gold In-Tube and T-SPOT.TB. J Infect. 2019;78(4):305-10.

5、Xin H, Zhang H, Cao X, Li X, Li M, Feng B, Jin Q, Gao L*. Serum level of IL-8 is associated with reversion of QuantiFERON-TB gold in-tube tests. J Infect. 2019 Apr;78(4):292-298.

6、Gao L*, Bai L, Liu J, Lu W, Wang X, Li X, Du J, Chen X, Zhang H, Xin H, Sui H, Li H, Su H, He J, Pan S, Peng H, Xu Z, Catanzaro A, Evans TG, Zhang Z, Ma Y, Li M, Feng B, Li Z, Guan L, Shen F, Wang Z, Zhu T, Yang S, Si H, Wang Y, Tan Y, Chen T, Chen C, Xia Y, Cheng S, Xu W, Jin Q*; LATENTTB-NSTM study team. Annual risk of tuberculosis infection in rural China: a population-based prospective study. Eur Respir J. 2016;48(1):168-78.

7、Gao L*, Zhang H, Xin H, Liu J, Pan S, Li X, Guan L, Shen F, Liu Z, Wang D, Guan X, Yan J, Li H, Feng B, Cao X, Chen Y, Cui W, Zhang Z, Ma Y, Chen X, Zhou X, Jin Q*; LATENTTB-NSTM study team. Short-course regimens of rifapentine plus isoniazid to treat latent tuberculosis infection in older Chinese patients: a randomised controlled study. Eur Respir J. 2018 Dec 20;52(6):1801470.

8、Xin H, Cao X, Zhang H, Feng B, Du Y, Zhang B, Wang D, Liu Z, Guan L, Shen F, Guan X, Yan J, He Y, He Y, Quan Z, Pan S, Liu J, Jin Q, Gao L*. Protective efficacy of 6-week regimen for latent tuberculosis infection treatment in rural China: 5-year follow-up of a randomised controlled trial. Eur Respir J. 2022 Jul 7;60(1):2102359.

9、Xin H, Cao X, Zhang H, Liu J, Pan S, Li X, Guan L, Shen F, Liu Z, Wang D, Guan X, Yan J, Li H, Feng B, Zhang M, Yang Q, Jin Q, Gao L*; LATENTTB-NSTM study team. Dynamic changes of interferon gamma release assay results with latent tuberculosis infection treatment. Clin Microbiol Infect. 2020;26(11):p1555.e1-7.

10、Xin H, Zhang H, Liu J, Pan S, Li X, Cao X, Feng B, Guan L, Shen F, Liu Z, Wang D, Yan J, Zhang M, Yang Q, Jin Q, Gao L*. Tuberculosis infection among the elderly in 20,486 rural residents aged 50-70 years old in Zhongmu County, China. Clin Microbiol Infect. 2019;25(9):1120-6.

11、Zhang H, Xin H, Du Y, Cao X, Pan S, Liu J, Guan L, Shen F, Liu Z, Zhang B, Wang D, Feng B, Du J, Guan X, He Y, He Y, Zhang Z, Yan J, Jin Q, Gao L*; LATENTTB TRIAL2-NSTM study team. Tuberculosis preventive treatment among individuals with inactive tuberculosis suggested by untreated radiographic abnormalities: a community-based randomized controlled trial. Emerg Microbes Infect. 2023 Dec;12(1):e2169195.

12、Xin H, Zhang H, Yang S, Liu J, Lu Wei, Bai L, Cao X, Feng B, Jin Q, Gao L*. 5-year follow-up of active tuberculosis development from latent infection in rural China. Clin Infect Dis. 2020;70(5):947-50.

13、Li H, Xin H, Qian S, Li X, Zhang H, Li M, Feng B, Jin Q, Gao L*. The testing of tuberculosis infection among the adolescents born after booster Bacillus Calmette-Guérin vaccination was terminated in China: Subgroup analysis of a population-based cross-sectional study. Front Med. 2017;11(4):528-535.

14、Li X, Yang Y, Liu J, Zhou F, Cui W, Guan L, Shen F, Gao C, Li M, Jin Q*, Gao L*. Treatment outcomes of pulmonary tuberculosis in the past decade in the mainland of China: a meta-analysis. Front Med. 2013;7(3):354-66.

15、He Y, Cao X, Guo T, He Y, Du Y, Zhang H, Feng B, Du J, Zhang B, Wang K, Yan J, Wang D, Liu Z, Pan S, Xin H*, Gao L*. Serial testing of latent tuberculosis infection in patients with diabetes mellitus using interferon-gamma release assay, tuberculin skin test, and creation tuberculin skin test. Front. Public Health. 2022. 10:1025550.