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劉海鷹

研究員
導師類别:博士生導師
性别: 女
學(xué)曆:博士研究生
學(xué)位:博士

個人簡介

中(zhōng)國(guó)醫(yī)學(xué)科(kē)學(xué)院/北京協和醫(yī)學(xué)院病原生物(wù)學(xué)研究所黨委副書記、紀委書記、課題組組長(cháng)。全國(guó)結核病防治綜合質(zhì)量控制專家指導委員會委員、中(zhōng)國(guó)免疫學(xué)會感染免疫分(fēn)會委員、中(zhōng)國(guó)防痨協會結核病基礎專業分(fēn)會常委。《中(zhōng)華結核和呼吸雜志(zhì)》和《結核與肺部疾病雜志(zhì)》編委。
主要研究方向是感染、炎症與免疫機制研究。主持或參與國(guó)家科(kē)技(jì )重大專項、國(guó)家重點研發計劃、國(guó)家自然科(kē)學(xué)基金、醫(yī)學(xué)與健康科(kē)技(jì )創新(xīn)工(gōng)程等多(duō)項國(guó)家級和院校級科(kē)研項目,參與多(duō)項戰略咨詢項目研究。在SCI收錄雜志(zhì)上發表學(xué)術論文(wén)30餘篇;獲得6項發明專利授權;獲得中(zhōng)華醫(yī)學(xué)科(kē)學(xué)技(jì )術獎二等獎(排名(míng)第五)、重大專項創新(xīn)團隊獎。

研究方向

結核病等我國(guó)重大傳染病免疫機制及新(xīn)型生物(wù)标識的研究。

科(kē)研項目

1.    國(guó)家重點研發計劃(2021-2026),結核病新(xīn)型診斷、治療、幹預手段及産(chǎn)品研發,課題骨幹。
2.    中(zhōng)國(guó)醫(yī)學(xué)科(kē)學(xué)院中(zhōng)央級公(gōng)益性科(kē)研院所基本科(kē)研業務(wù)費(2020-2022),西藏自治區(qū)結核病流行菌株特征及緻病特點研究,課題負責人。
3.    國(guó)家自然科(kē)學(xué)基金委員會面上項目(2021-2024),血管生成素2參與活動性肺結核免疫機制研究,課題負責人。
4.    中(zhōng)國(guó)工(gōng)程院咨詢研究項目(2019-2020 ),中(zhōng)國(guó)與法國(guó)等發達國(guó)家結核病防治體(tǐ)系的對比研究,課題骨幹。
5.    國(guó)家外專局高端外國(guó)專家項目(2018-1019),結核病新(xīn)型分(fēn)子标識研究,課題負責人。
6.    國(guó)家科(kē)技(jì )重大專項 (2017-2020),菌陰結核病和結核分(fēn)枝杆菌潛伏感染相關生物(wù)标志(zhì)物(wù)研究,子課題負責人。
7.    中(zhōng)國(guó)醫(yī)學(xué)科(kē)學(xué)院醫(yī)學(xué)與健康科(kē)技(jì )創新(xīn)工(gōng)程項目(2016-2021),感染性疾病(結核病等)診治新(xīn)策略研究,課題骨幹。
8.    國(guó)家自然科(kē)學(xué)基金委員會面上項目(2012-2015),接頭蛋白Gab2調控結核病發生、發展的免疫學(xué)功能(néng)研究,課題負責人。
9.    國(guó)家科(kē)技(jì )重大專項 (2012-2015),結核病分(fēn)子标識的研究,課題負責人。
10.    國(guó)家科(kē)技(jì )重大專項(2008-2010),結核病免疫保護機制研究,課題負責人。
11.    國(guó)家科(kē)技(jì )重大專項 (2008-2010),結核病診斷分(fēn)子标識研究,子課題負責人。

研究成果

1.    Dong, H., Y. Zhang, Y. Zou, Y. Chen, J. Yue, H. Liu and X. Jiang (2021). "Elevated chemokines concentration is associated with disease activity in Takayasu arteritis." Cytokine 143: 155515.
2.    Li, H., L. Liu, W. J. Zhang, X. Zhang, J. Zheng, L. Li, X. Zhu, Q. Yang, M. Zhang, H. Liu, X. Chen and Q. Jin (2019). "Analysis of the Antigenic Properties of Membrane Proteins of Mycobacterium tuberculosis." Sci Rep 9(1): 3042.
3.    Liu, C. H., H. Liu and B. Ge (2017). "Innate immunity in tuberculosis: host defense vs pathogen evasion." Cell Mol Immunol 14(12): 963-975.
4.    Hu, Y., Y. Zhang, X. Ren, Y. Liu, Y. Xiao, L. Li, F. Yang, H. Su, F. Liu, H. Liu, B. Cao and Q. Jin (2016). "A case report demonstrating the utility of next generation sequencing in analyzing serial samples from the lung following an infection with influenza A (H7N9) virus." J Clin Virol 76: 45-50.
5.    Yu, Y., D. Jin, S. Hu, Y. Zhang, X. Zheng, J. Zheng, M. Liao, X. Chen, M. Graner, H. Liu and Q. Jin (2015). "A novel tuberculosis antigen identified from human tuberculosis granulomas." Mol Cell Proteomics 14(4): 1093-1103.
6.    Zhang, M., G. Zeng, Q. Yang, J. Zhang, X. Zhu, Q. Chen, P. Suthakaran, Y. Zhang, Q. Deng, H. Liu, B. Zhou and X. Chen (2014). "Anti-tuberculosis treatment enhances the production of IL-22 through reducing the frequencies of regulatory B cell." Tuberculosis (Edinb) 94(3): 238-244.
7.    Liu, L., W. J. Zhang, J. Zheng, H. Fu, Q. Chen, Z. Zhang, X. Chen, B. Zhou, L. Feng, H. Liu and Q. Jin (2014). "Exploration of novel cellular and serological antigen biomarkers in the ORFeome of Mycobacterium tuberculosis." Mol Cell Proteomics 13(3): 897-906.
8.    Hu, S., Y. Zhang, Y. Yu, D. Jin, X. Zhang, S. Gu, H. Jia, X. Chen, Z. Zhang, Q. Jin, Y. Ke and H. Liu (2014). "Growth factor receptor bound protein 2-associated binder 2, a scaffolding adaptor protein, negatively regulates host immunity against tuberculosis." Am J Respir Cell Mol Biol 51(4): 575-585.
9.    Zhang, Y., H. Liu, L. Wang, F. Yang, Y. Hu, X. Ren, G. Li, Y. Yang, S. Sun, Y. Li, X. Chen, X. Li and Q. Jin (2013). "Comparative study of the cytokine/chemokine response in children with differing disease severity in enterovirus 71-induced hand, foot, and mouth disease." PLoS One 8(6): e67430.
10.    Yu, Y., Y. Zhang, S. Hu, D. Jin, X. Chen, Q. Jin and H. Liu (2012). "Different patterns of cytokines and chemokines combined with IFN-gamma production reflect Mycobacterium tuberculosis infection and disease." PLoS One 7(9): e44944.
11.    Qiu, Z., M. Zhang, Y. Zhu, F. Zheng, P. Lu, H. Liu, M. W. Graner, B. Zhou and X. Chen (2012). "Multifunctional CD4 T cell responses in patients with active tuberculosis." Sci Rep 2: 216.
12.    Liu, K., Y. Zhang, S. Hu, Y. Yu, Q. Yang, D. Jin, X. Chen, Q. Jin and H. Liu (2012). "Increased levels of BAFF and APRIL related to human active pulmonary tuberculosis." PLoS One 7(6): e38429.
13.    Zhang, M., Z. Wang, M. W. Graner, L. Yang, M. Liao, Q. Yang, J. Gou, Y. Zhu, C. Wu, H. Liu, B. Zhou and X. Chen (2011). "B cell infiltration is associated with the increased IL-17 and IL-22 expression in the lungs of patients with tuberculosis." Cell Immunol 270(2): 217-223.
14.    Bai, X., K. Chmura, A. R. Ovrutsky, R. P. Bowler, R. I. Scheinman, R. E. Oberley-Deegan, H. Liu, S. Shang, D. Ordway and E. D. Chan (2011). "Mycobacterium tuberculosis increases IP-10 and MIG protein despite inhibition of IP-10 and MIG transcription." Tuberculosis (Edinb) 91(1): 26-35.
15.    Chen, X., M. Zhang, X. Zhu, Q. Deng, H. Liu, N. Larmonier, M. W. Graner and B. Zhou (2009). "Engagement of Toll-like receptor 2 on CD4(+) T cells facilitates local immune responses in patients with tuberculous pleurisy." J Infect Dis 200(3): 399-408.
16.    Niedbala, W., B. Cai, H. Liu, N. Pitman, L. Chang, and F.Y. Liew, Nitric oxide induces CD4+CD25+ Foxp3 regulatory T cells from CD4+CD25 T cells via p53, IL-2, and OX40. Proc Natl Acad Sci U S A, 2007. 104(39): p. 15478-83.
17.    Liu, H. and B.P. Leung, CD4+CD25+ regulatory T cells in health and disease. Clin Exp Pharmacol Physiol, 2006. 33(5-6): p. 519-24.
18.    Liu, H., M. Komai-Koma, D. Xu, and F.Y. Liew, Toll-like receptor 2 signaling modulates the functions of CD4+ CD25+ regulatory T cells. Proc Natl Acad Sci U S A, 2006. 103(18): p. 7048-53.
19.    Liew, F.Y., H. Liu, and D. Xu, A novel negative regulator for IL-1 receptor and Toll-like receptor 4. Immunol Lett, 2005. 96(1): p. 27-31.
20.    Xu, D., H. Liu, and M. Komai-Koma, Direct and indirect role of Toll-like receptors in T cell mediated immunity. Cell Mol Immunol, 2004. 1(4): p. 239-46.
21.    Brint, E.K., D. Xu, H. Liu, A. Dunne, A.N. McKenzie, L.A. O'Neill, and F.Y. Liew, ST2 is an inhibitor of interleukin 1 receptor and Toll-like receptor 4 signaling and maintains endotoxin tolerance. Nat Immunol, 2004. 5(4): p. 373-9
22.    Xu, D., H. Liu, M. Komai-Koma, C. Campbell, C. McSharry, J. Alexander, and F.Y. Liew, CD4+CD25+ regulatory T cells suppress differentiation and functions of Th1 and Th2 cells, Leishmania major infection, and colitis in mice. J Immunol, 2003. 170(1): p. 394-9.
23.    Liu, H., B. Hu, D. Xu, and F.Y. Liew, CD4+CD25+ regulatory T cells cure murine colitis: the role of IL-10, TGF-beta, and CTLA4. J Immunol, 2003. 171(10): p. 5012-7.

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研究生培養

培養博士研究生4名(míng),碩士研究生4名(míng),3名(míng)碩士研究生在讀。