中(zhōng)國(guó)醫(yī)學(xué)科(kē)學(xué)院北京協和醫(yī)學(xué)院病原生物(wù)學(xué)研究所研究員，博士生導師。主要從事呼吸道病毒與宿主相互作(zuò)用(yòng)機制及其感染緻病機制的研究。主持國(guó)家傳染病重大專項和國(guó)家自然科(kē)學(xué)基金面上項目等多(duō)項國(guó)家級科(kē)研項目。在Nat Commun、Signal Transduct Target Ther、Cell Rep、PLoS Pathog、J Biol Chem、J Virol、Natl Sci Rev和FASEB J等SCI收錄雜志(zhì)上發表SCI論文(wén)24篇。入選2020年Springer Nature中(zhōng)國(guó)學(xué)者年度高影響力研究，2022年斯坦福大學(xué)全球前2%頂尖科(kē)學(xué)家榜單。目前擔任中(zhōng)國(guó)微生物(wù)學(xué)會病毒學(xué)專業委員會委員和中(zhōng)華預防醫(yī)學(xué)會醫(yī)學(xué)病毒學(xué)分(fēn)會青年小(xiǎo)組委員。

重要呼吸道病毒與宿主相互作(zuò)用(yòng)研究

1.  國(guó)家自然科(kē)學(xué)基金面上項目，GSDME介導的細胞焦亡在腸道病毒71型感染緻病機制中(zhōng)的作(zuò)用(yòng)研究，81971948，課題負責人；
2.  國(guó)家傳染病重大專項，基于人類全基因組編碼及非編碼區(qū)高通量篩選的抗病毒靶标發現新(xīn)技(jì )術研究，ZX201810301401，課題負責人；
3.  國(guó)家自然科(kē)學(xué)基金面上項目，高爾基體(tǐ)ACBD3蛋白複合物(wù)參與EV71複制的分(fēn)子機制研究，81672032，課題負責人；
4.  中(zhōng)國(guó)醫(yī)學(xué)科(kē)學(xué)院醫(yī)學(xué)與健康科(kē)技(jì )創新(xīn)工(gōng)程，抗感染藥物(wù)/疫苗快速評測與開發，2016-I2M-1-005，子課題負責人；
5.  國(guó)家重點研發計劃，新(xīn)型冠狀病毒感染複制關鍵宿主因子及其作(zuò)用(yòng)機制研究，2020YFA0707600，課題骨幹；
6.  國(guó)家自然科(kē)學(xué)基金重點項目，重要腸道病毒感染複制關鍵宿主因子全景式篩選及其作(zuò)用(yòng)分(fēn)子機制研究，81930063，2020.01-2024.12，課題骨幹。

代表性論文(wén)：(# 共同第一作(zuò)者；* 共同通訊作(zuò)者)
1.    Zhang D#, Qiao L#, Lei X#, Dong X, Tong Y, Wang J*, Wang Z*, Zhou R*. Mutagenesis and structural studies reveal the basis for the specific binding of SARS- CoV-2 SL3 RNA element with human TIA1 protein. Nat Commun. 2023 Jun 22; 14(1):3715.
2.    Wu Z#, Lei X#, Wang X#, Zhang Z, Li Y, Gao L, Liang X, Wang P, Wang J*, Ma C*. Peptide targeting the interaction of S protein cysteine-rich domain with Ezrin restricts pan-coronavirus infection. Signal Transduct Target Ther. 2023 Jan 18;8(1):19.
3.     Guo S#, Lei X#, Chang Y#, Zhao J#, Wang J#, Dong X, Liu Q, Zhang Z, Wang L, Yi D, Ma L, Li Q, Zhang Y, Ding J, Liang C, Li X, Guo F*, Wang J*, Cen S*. SARS-CoV-2 hijacks cellular kinase CDK2 to promote viral RNA synthesis. Signal Transduct Target Ther. 2022 Dec 27;7(1):400.
4.    Dong S#, Shi Y#, Dong X, Xiao X, Qi J, Ren L, Xiang Z, Zhou Z, Wang J*, Lei X*. Gasdermin E is required for induction of pyroptosis and severe disease during enterovirus 71 infection. J Biol Chem. 2022 May; 298(5): 101850.
5.    Zhou Z#, Zhang X#, Lei X#, Xiao X#, Jiao T, Ma R, Dong X, Jiang Q, Wang W, Shi Y, Zheng T, Rao J, Xiang Z, Ren L, Deng T, Jiang Z, Dou Z, Wei W*, Wang J*. Sensing of cytoplasmic chromatin by cGAS activates innate immune response in SARS-CoV-2 infection. Signal Transduct Target Ther. 2021 Nov 3; 6(1):382.
6.    Wang W#, Zhou Z#, Xiao X#, Tian Z, Dong X, Wang C, Li L, Ren L, Lei X*, Xiang Z*, Wang J*. SARS-CoV-2 nsp12 attenuates type I interferon production by inhibiting IRF3 nuclear translocation. Cell Mol Immunol. 2021,18(4):945-953.
7.    Lei X#, Dong X#, Ma R#, Wang W, Xiao X, Tian Z, Wang C, Wang Y, Li L, Ren L, Guo F, Zhao Z, Zhou Z*, Xiang Z*, Wang J*. Activation and evasion of type I interferon responses by SARS-CoV-2. Nat Commun, 2020, 11(1): 3810.
8.    Lei X#, Zhang Z#, Xiao X, Qi J, He B*, Wang J*. Enterovirus 71 Inhibits Pyroptosis through Cleavage of Gasdermin D. J Virol. 2017, 91(18): e01069-17.
9.    Xiao X#, Lei X#, Zhang Z, Ma Y, Qi J,Wu C, Xiao Y, Li L, He B*, Wang J*. Enterovirus 3A facilitates viral replication by promoting Phosphatidylinositol4-kinaseIIIβ-ACBD3 interaction. J Virol. 2017, 91(19): e00791-17.
10.    Wang H#, Lei X#, Xiao X, Yang C, Lu W, Huang Z, Leng Q, Jin Q, He B, Meng G*, Wang J*. Reciprocal Regulation between Enterovirus 71 and the NLRP3 Inflammasome. Cell Rep. 2015, 12(1): 42-48.
11.    Lei X#, Cui Sheng, Zhao Z*, Wang J*. Etiology, pathogenesis, antivirals and vaccines of hand, foot, and mouth disease. Natl Sci Rev. 2015, 2 (3): 268-284.
12.    Lei X#, Han N#, Xiao X, Jin Q*, He B*, Wang J*. Enterovirus 71 3C inhibits cytokine expression through cleavage of the TAK1/TAB1/TAB2/TAB3 complex.  J Virol. 2014, 88(17): 9830-9841.
13.    Lei X, Xiao X，Xue Q，Jin Q*, He B*, Wang J*. Cleavage of Interferon Regulatory Factor 7 by Enterovirus 71 3C Suppresses Cellular Responses. J Virol. 2013，87（3）：1690-1698.
14.    Lei X#, Sun Z#, Liu X, Jin Q*, He B*, Wang J*.Cleavage of the adaptor protein TRIF by enterovirus 71 3C inhibits antiviral responses mediated by Toll-like receptor 3，J Virol. 2011，85（17）：8811-8818.
15.    Lei X, Liu X, Ma Y, Sun Z, Yang Y, Jin Q*, He B*, Wang J*. The 3C protein of enterovirus 71 inhibits retinoid acid-inducible gene I-mediated interferon regulatory factor 3 activation and type I interferon responses. J Virol. 2010, 84(16): 8051-8061.

團隊累計培養研究生、博士後10人次